CHRONIC DERMATOSES AND OBESITY: COMORBIDITY ISSUES
DOI:
https://doi.org/10.34132/mspc2025.01.08.16Keywords:
chronic dermatoses, obesity, comorbidity, body mass index, eating behavior, depression.Abstract
The theses analyze the clinical and pathophysiological interrelation between chronic dermatoses (CD) and obesity as an example of comorbid pathology. It has been established that obesity aggravates the course of skin diseases due to enhanced systemic inflammation, metabolic and immune dysfunctions. During 2023–2024, a clinical evaluation of 1,348 patients with chronic skin diseases was conducted at the university clinic. Among them, 249 (18.5%) were diagnosed with obesity (BMI ≥30 kg/m²), including 145 women (58.2%) and 104 men (41.8%). The most common diagnoses in this subgroup included psoriasis (32.1%), atopic dermatitis (26.1%), chronic urticaria (14.9%), eczema (12%), and seborrheic dermatitis (8%). Patients with obesity had more severe disease courses and a higher prevalence of anxiety (42%) and depressive (38%) disorders. Women primarily showed restrictive eating behaviors, while men tended to display external eating patterns. A multidisciplinary approach involving dermatologists, psychotherapists, and dietitians is necessary. Lifestyle modification and psychological support programs can improve both dermatological and metabolic health outcomes.
References
Vsesvitna orhanizatsiia okhorony zdorov ya. Ozhyrinnia i nadlyshkova vaha. – 2022. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight
Gisondi P., Fostini A.C., Fossà I., Girolomoni G., Targher G. Psoriasis and the metabolic syndrome. Clin Dermatol. 2018;36(1):21-28. https://doi.org/10.1016/j.clindermatol.2017.09.005
Jensen P., Zachariae C., Christensen R., Geiker N.R.W., Schaadt B.K., Stender S., et al. Effect of weight loss on the severity of psoriasis: a randomized clinical study. JAMA Dermatol. 2013;149(7):795-801.
Verma S.B., Wollina U. Obesity and skin: a dermatologic overview. J Cutan Aesthet Surg. 2012;5(1):12–15.
Krajewska-Włodarczyk M., Owczarczyk-Saczonek A., Wygonowska E., Placek W. Metabolic syndrome and its components in psoriatic patients: a case-control study. Postepy Dermatol Alergol. 2020;37(4):560-566.
Kromer C., Celis D., Patel P., Ahn C., Kimball A. The impact of obesity on quality of life in psoriasis. Int J Dermatol. 2021;60(8):e304-e309.
Griffiths C.E., Armstrong A.W., Gudjonsson J.E., Barker J.N. Psoriasis. Lancet. 2021;397(10281):1301–1315.
Takahashi H., Tsuji H., Honma M., Ishida-Yamamoto A., Iizuka H. Increased plasma resistin and decreased omentin levels in Japanese patients with psoriasis. Arch Dermatol Res. 2013;305(2):113–116.
Langan S.M., Seminara N.M., Shin D.B., Troxel A.B., Kimmel S.E., Mehta N.N. Prevalence of metabolic syndrome in patients with psoriasis: a population-based study in the United Kingdom. J Invest Dermatol. 2012;132(3 Pt 1):556–562.
Arnold L.M., Hudson J.I., Keck P.E. Comorbidity of chronic medical conditions in individuals with major depressive disorder: the impact on quality of life. J Clin Psychiatry. 2006;67(5):743-750.
Sominsky L., Spencer S.J. Eating behavior and stress: a pathway to obesity. Front Psychol. 2014;5:434.
Weller C., Rademaker M. The effects of obesity on skin disease. Aust J Dermatol. 2020;61(3):199–206.
