PHARMACOLOGICAL AND NON-PHARMACOLOGICAL APPROACHES TO MODULATING MALADAPTIVE NEUROPLASTICITY
DOI:
https://doi.org/10.34132/mspc2025.01.08.40Keywords:
rehabilitation, treatment, neuroplasticity, chronic pain, depression, post-traumatic stress disorder, obsessive-compulsive disorder, addictionsAbstract
The abstract presents an analysis of current strategies aimed at influencing central nervous system neuroplasticity with the goal of preventing maladaptive neuronal changes. Both pharmacological and non-pharmacological approaches are discussed, with a particular emphasis on the interdisciplinary approach as the most promising for correcting pathological neuroplasticity and restoring neurofunctional homeostasis. The role of physical therapy and aerobic exercise in modulating neuroplasticity processes is examined. Among non-pharmacological methods, significant attention is given to cognitive-behavioral therapy, biofeedback techniques, mindfulness meditation, neurofeedback, physical rehabilitation, and the use of non-invasive neuromodulation.
References
Puderbaugh M, Emmady PD. Neuroplasticity. [Updated 2023 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557811/
Li XY, Wan Y, Tang SJ, Guan Y, Wei F, Ma D. Maladaptive Plasticity and Neuropathic Pain. Neural Plast. 2016;2016:4842159. doi: 10.1155/2016/4842159. Epub 2016 Jan 27. PMID: 26925270; PMCID: PMC4748137.
Lotze M. Maladaptive Plastizität bei chronischen und neuropathischen Schmerzen [Maladaptive plasticity in chronic and neuropathic pain]. Schmerz. 2016 Apr;30(2):127-33. German. doi: 10.1007/s00482-015-0080-7. PMID: 26692212.
Jayathilake NJ, Phan TT, Kim J, Lee KP, Park JM. Modulating neuroplasticity for chronic pain relief: noninvasive neuromodulation as a promising approach. Exp Mol Med. 2025 Mar;57(3):501-514. doi: 10.1038/s12276-025-01409-0. Epub 2025 Mar 3. PMID: 40025172; PMCID: PMC11958754.
Moore RA, Wiffen PJ, Derry S, Toelle T, Rice AS. Gabapentin for chronic neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev. 2014 Apr 27;2014(4):CD007938. doi: 10.1002/14651858.CD007938.pub3. Update in: Cochrane Database Syst Rev. 2017 Jun 09;6:CD007938. doi: 10.1002/14651858.CD007938.pub4. PMID: 24771480; PMCID: PMC6464253.
Fernandez-Espejo E, Rodriguez-Espinosa N. Psychostimulant Drugs and Neuroplasticity. Pharmaceuticals (Basel). 2011 Jun 30;4(7):976–91. doi: 10.3390/ph4070976. PMCID: PMC4058673.
Thomas J, Fauchon C, Oriol N, Vassal F, Créac’h C, Quesada C, Peyron R. Effects of multiple transcranial magnetic stimulation sessions on pain relief in patients with chronic neuropathic pain: A French cohort study in real-world clinical practice. Eur J Pain. 2025 Jan;29(1):e4763. doi: 10.1002/ejp.4763. PMID: 39655628; PMCID: PMC11629460.
Sharma M, Farahani F, Bikson M, Parra LC. Weak DCS causes a relatively strong cumulative boost of synaptic plasticity with spaced learning. Brain Stimul. 2022 Jan-Feb;15(1):57-62. doi: 10.1016/j.brs.2021.10.552. Epub 2021 Nov 5. PMID: 34749007; PMCID: PMC8816825.
Motolese F, Capone F, Di Lazzaro V. New tools for shaping plasticity to enhance recovery after stroke. Handb Clin Neurol. 2022;184:299-315. doi: 10.1016/B978-0-12-819410-2.00016-3. PMID: 35034743.
Ferrazzoli D, Ortelli P, Iansek R, Volpe D. Rehabilitation in movement disorders: From basic mechanisms to clinical strategies. Handb Clin Neurol. 2022;184:341-355. doi: 10.1016/B978-0-12-819410-2.00019-9. PMID: 35034747.
Khramtsov D.N., Stoyanov O.N., Muratova T.N., Pulyk O.R. Neurorehabilitation in the Early Recovery Period of Ischemic Stroke. Pharmacology Support // Acta Balneologica. – 2021. – Vol. 63, N1(61). – P. 22-25
Храмцов Д. М., Стоянов О. М., Грузевський О. А., Шевчук Г. Ю. Комплексна нейрореабілітація постінсультних хворих // Медична наука України. – 2022. – Vol. 18, N3. – P. 52-59
Mojtabavi H, Shaka Z, Momtazmanesh S, Ajdari A, Rezaei N. Circulating brain-derived neurotrophic factor as a potential biomarker in stroke: a systematic review and meta-analysis. J Transl Med. 2022 Mar 14;20(1):126. doi: 10.1186/s12967-022-03312-y. PMID: 35287688; PMCID: PMC8919648.
Freidle M, Johansson H, Ekman U, Lebedev AV, Schalling E, Thompson WH, Svenningsson P, Lövdén M, Abney A, Albrecht F, Steurer H, Leavy B, Holmin S, Hagströmer M, Franzén E. Behavioural and neuroplastic effects of a double-blind randomised controlled balance exercise trial in people with Parkinson’s disease. NPJ Parkinsons Dis. 2022 Jan 21;8(1):12. doi: 10.1038/s41531-021-00269-5. PMID: 35064138; PMCID: PMC8782921.
Romero Garavito A, Díaz Martínez V, Juárez Cortés E, Negrete Díaz JV, Montilla Rodríguez LM. Impact of physical exercise on the regulation of brain-derived neurotrophic factor in people with neurodegenerative diseases. Front Neurol. 2025 Jan 28;15:1505879. doi: 10.3389/fneur.2024.1505879. PMID: 39935805; PMCID: PMC11810746.
